Abstract: Objective :To analyze the clinical manifestations, diagnosis, therapy and prognosis of primary gastrointestinal non-Hodgkin's lymphoma (PGIL). Methods :Forty-five cases of astrointestinal Non-Hodgkin'slymphoma were studied retrospectively. Results :The group's two-year survival rate was82.8%.Significant differences were manifested among groups of different histological classification by Log-rank test. Cox multivariate analysis revealed that histological type worked as a prognostic factor other than indices like sex, age, staging, presence of B-symptoms and level of infiltration. Conclusions :Regular therapy of resection combined with chemotherapy may improve the treatment for patients withPGIL at early stage. The histological type of the PGIL is one of the most important prognostic factors.